Panobinostat, also known as LBH-589, is a highly active, non-selective HDAC inhibitor. IC50’s against HDAC s 1-9 range between 3 – 61 nM except for a slightly higher IC50 value of 248 nM for HDAC 8. Panobinostat inhibits tumor cell proliferation and induces apoptosis in breast cancer and T cell lymphoma cells. In addition to its tumor-suppressive activities, panobinostat induces histone H3K9 and histone H4K8 acetylation and decreases the level of c-Myc expression.
| 产品名称 | Panobinostat - Inhibitors / Activators - Deacetylase(s) |
| 产品货号 | 27020 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 349.4 Da
CAS Registry #: 404950-80-7
Formula: C21H23N3O2
Description: Synonym(s): Faridak, LBH-589
Purity: ≥99% Solubility: Soluble in DMSO at 200 mg/ml; soluble in ethanol at 5 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-50 µM buffers, serum, or other additives may increase or decrease the aqueous solubility. Format: Yellow solid
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s): 1. Zhou Q, et al. H Cancer Biol Ther 2007; 6(1):64-69.
2. Ellis L, Pan Y et al. Clin Cancer Res 2008; 14(14):4500-4510. Scientific Category: HDAC
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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