| 产品名称 | Sirtinol |
| 产品货号 | 27652-2 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 25 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 394.5 Da
CAS Registry #: 410536-97-9
Formula: C26H22N2O2
Target: SIRT1, SIRT2
Background: Unlike TSA, Sirtinol does not inhibit class I and class II HDACs, indicating that it is a selective sirtuin inhibitor. The downregulation of SIRT1/2 expression plays an important role in the regulation of breast cancer apoptosis; thus, SIRT1/2 may be a novel molecular target for cancer therapy.
Description: Cell-permeable, selective sirtuin inhibitor that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.
Synonym(s): 2-[[(Z)-(2-oxonaphthalen-1-ylidene)methyl]amino]-N-(1-phenylethyl)benzamide
Purity: ≥98% by HPLC Solubility: DMSO 23 mg/ml, Water <1 mg/ml, Ethanol <1 mg/ml
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): 1. Wang J,et al. Int J Oncol. 2012 Sep;41(3):1101-9.
2. Grozinger CM, et al. J Biol Chem. 2001 Oct 19;276(42):38837-43. Scientific Category: Deacetylase Inhibitor
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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