Human T-cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as V-set and immunoglobulin domain-containing protein 9, VSIG9, V-set and transmembrane domain-containing protein 3, and VSTM3, GenBank Accession No. NM_173799, a.a. 22-141 fused to Fc region of human IgG, expressed in a HEK293 cell expression system. MW = 39.7 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.

Q495A1

T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, VSIG9, V-set and transmembrane domain-containing protein 3, VSTM3

<1 EU/μg

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.

Aqueous buffer solution

At least 6 months at –80°C.

Useful for studying protein binding and for screening small molecules and antibodies.

1. Yu, X., et al., Nat. Immunol. 2009; 10(1): 48-57.
2. Stanietsky, N., et al., Proc. Natl. Acad. Sci. (USA). 2009; 106(42): 17858-17863.

The aggregation state of this product has been confirmed to be <10%.

Avoid freeze/thaw cycles. Protein may be diluted to ≥ 100 μg/ml in PBS + glycerol and stored at -80°C.

Immunotherapy

Fc fusion protein