| 产品名称 | OTX-015 |
| 产品货号 | 27636-3 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 25 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 492 Da
CAS Registry #: 202590-98-5
Formula: C25H22ClN5O2S
Background: Bromodomains have an important role in the targeting of chromatin-modifying enzymes to specific sites, including methyltransferases, HATs and transcription factors and regulate diverse biological processes from cell proliferation and differentiation to energy homeostasis and neurological processes.
Description: OTX-015 is a potent new BRD-inhibitor with evident anti-proliferative activity in several cell lines representative of mature B-cell tumors.
Synonym(s): OTX 015; OTX015
Purity: ≥98% by HPLC Biological Activity: OTX-015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4. IC50 Value: 0.192 uM (DLBCL cell lines). In vitro, OTX-015 demonstrated anti-proliferative activity in DLBCL cell lines (median IC50 0.192 µM). Similar results were obtained on SMZL (median IC50 0.165 µM), and on MM cell lines (median IC50 0.449 µM). MCL cell lines appeared less sensitive to OTX-015 (median IC50 2.01 µM). Among DLBCL cell lines, there was no difference based upon the cell of origin of the cell lines.
Solubility: Soluble in DMSO
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): 1. Noel, J.K., et al. Mol. Cancer Ther. 12 , C244 (2013).
2. Braun, T., et al. Blood 122, 4218 (2014). Scientific Category: Bromodomain Inhibitor
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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