| 产品名称 | FALZ (BPTF), His-tag |
| 产品货号 | 31131 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 100 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 15.2 kDa
Genbank #: NM_182641
Tag(s): N-terminal His-tag
a.a: 2791–2911
Background: FALZ is a bromodomain-containing protein that is the histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on Lys4 (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. High levels of FALZ were detected in fetal brain and in patients with neurodegenerative diseases.
Description: Human Fetal Alzheimer Antigen (FALZ), lso known as Fetal Alz-50 Clone 1 Protein or bromodomain PHD finger transcription factor (BPTF), GenBank Accession No. NM_182641, a.a. 2791-2911 corresponding to single bromodomain, with N-terminal His-tag, MW=15.2 kDa, expressed in an E. coli expression system.
UniProt Q12830
Synonym(s): Bromodomain and PHD finger containing 4, FALZ, BPTF, fetal Alzheimer antigen
Formulation: 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 225 mM imidazole, 3 mM DTT, and 10% glycerol.
Format: Aqueous buffer solution
Storage / Stability: >6 months at –80°C. Application(s): Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Reference(s): 1. Buganim, Y., et al.,Structure. PLoS One. 2010;11;5(3):e9657.
2. Ruthenburg, A.J., et al., Cell. 2011;145(5):692-706. Warning(s): Avoid freeze/thaw cycles.
Scientific Category: Bromodomain
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
|
| 产品资料 |
