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产品名称 Anti–RbAp 46/48 monoclonal antibody - Antibodies
产品货号 25311
产品价格 现货询价，电话：010-67529703
产品规格 50 µg
产品品牌 bpsbioscience
产品概述
产品详情
Host Species: Mouse
Clonality: monoclonal
Isotype: IgG2b
Background:
RbAp48 (UniProtKB/Swiss–Prot entry Q09028) is a component of several complexes which regulate chromatin metabolism. These include (1) the chromatin assembly factor 1 (CAF–1) complex, which is required for chromatin assembly following DNA replication and DNA repair; (2) the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; (3) the nucleosome remodelling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; (4) the PRC2/EED–EZH2 complex, which promotes repression of homeotic genes during development; and (5) the NURF (nucleosome remodeling factor) complex. Therefore it may target chromatin assembly factors as well as chromatin remodeling factors and histone deacetylases to their histone substrates in a nucleosomal DNA dependent manner.
Description:
Monoclonal antibody raised in mouse against the full length human RbAp48 protein (Retinoblastoma–binding protein p48) fused to GST. The antibody recognizes both RbAp48 and RbAp46.
Synonym(s):
RBBP7/4, RBBP–7/4, RBAP46/48, NURF 55
Assay Conditions:

Western blot analysis using the monoclonal antibody directed against hRbAp46/48
Western blot was performed using nuclear extracts from HeLa cells (HeLa NE, 20 μg) and the monoclonal antibody against hRbAp46/48 (cat. #25311) diluted 1:1,000 in TBS-Tween containing 5% skimmed milk. The molecular weight marker (in kDa) is shown on the left), the position of the protein of interest is shown on the right.

Concentration:
50 µg/25 µl
Formulation:
PBS containing 0.05% azide and 0.05% ProClin 300.
Species Reactivity:
Human
Purification:
Protein G purified
Immunogen:
recombinant protein
Format:
Aqueous buffer solution
Storage / Stability:

Store at –80°C for up to 2 years. Centrifuge after first thaw to maximize product recovery. Aliquot to avoid repeated freeze/thaw cycles. Aliquots may be stored at –20°C for at least one month.

Application(s):
WB (1:1000)
Notes:
The optimal antibody concentration should be determined by the end–user.
Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Antibodies
Product Type:
Antibody
Data shown is lot-specific. Contact us for specific information on other lots.

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