| 产品名称 | TDO Inhibitor Screening Assay Kit -384 - Metabolic Enzymes |
| 产品货号 | 72036 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 384 reactions |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Background: L-tryptophan (L-Trp) is an essential amino acid necessary for protein
synthesis in mammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as
a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an
immunosuppressive microenvironment by starving immune cells of L-Trp and releasing
degradation products of L-Trp that have immunosuppressive functions. Tryptophan 2,3
dioxygenase (TDO) is upregulated in many tumors, providing cancer cells with an avenue for
immune evasion.
Description: The TDO Inhibitor Screening Assay Kit is designed to measure TDO enzyme inhibition. The TDO Inhibitor Screening Assay Kit is simple to use. Inhibitor and enzyme are added to a sample containing L-Trp substrate. After a room temperature incubation, activity is measured by measuring the absorption of reaction product at = 320-325 nm. Synonym(s): TDO2, tryptophan 2,3 dioxygenase, activity assay kit
Supplied As: The kit comes in a convenient format, with enough reaction solution and enzyme to perform a total of 400 reactions.
Contraindications: DMSO >1%, strong acids or bases, ionic detergents, high salt
Format: COMPONENTS:
Instructions for use: See assay kit data sheet for detailed protocol
Storage / Stability: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Application(s): Useful for the study of TDO enzymology, screening inhibitors and selectivity profiling.
Reference(s): Li, J.S., et al. Arch. Insect Biochem. Physiol. 2007 Feb; 64(2): 74–87. Warning(s): Avoid freeze/thaw cycles.
Scientific Category: Immunotherapy
Product Type: Assay Kit
Data shown is lot-specific. Contact us for specific information on other lots.
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