| 产品名称 | Sestrin 1, FLAG-tag - Proteins - Immunotherapy |
| 产品货号 | 50284 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 50 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 65 kDa
Genbank #: NM_014454
Tag(s): N-terminal FLAG-tag
a.a: 2–551(end)
Background: Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. Sestrin 1 mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mTOR protein. Sestrin 1 in important for antioxidant defense because it regenerates overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation.
Description: Human Sestrin1, also known as p53-regulated protein PA26 (GenBank Accession No. NM_014454), full length, a.a. 2-551(end), with N-terminal FLAG-tag, MW=65 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
UniProt Q9Y6P5
Synonym(s): Sestrin-1, PA26, SEST1, P53-Regulated Protein PA26
Formulation: 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 3 mM DTT, 90 ?g/ml FLAG peptide and 10% glycerol
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Lee, J.H., et al. (2010). Science 327(5970): 1223-8.
2. Broderick, G., et al., (2006). Pharmacogenomics 7(3): 407-419. 3. Budanov AV, Karin M. (2008). Cell 134 (3): 451-460. 4. Hay, N. (2008). Cell Metab. 8(3):184-5. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Immunotherapy
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
|
| 产品资料 |
