| 产品名称 | CD112R (PVRIG), Fc-Fusion, Avi-Tag, Biotin-Labeled (Human) HiP™ - Proteins - Immunotherapy |
| 产品货号 | 79270 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 50 μg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: HEK293
MW: 42 kDa
Genbank #: NM_024070
Tag(s): C-terminal Fc-Fusion- Avi-Tag
a.a: 41-172
Background: PVRIG (CD112R) is an regulatory protein expressed on T-cells which inhibits immune activation when binding to its counterpart on APCs, PVRL2 (CD112, Nectin-2). Since both PVRL2 and PVR can activate DNAM-1 (CD226), PVRIG works synergistically with and separately from TIGIT. PVRL2 is overexpressed in a variety of tumor types, including breast and ovarian cancers, suggesting that its interaction with PVRIG is a major mechanism of immune suppression in those diseases.
Description: Human secreted CD112R, also known as Poliovirus Receptor-related Immunoglobulin Domain-containing Protein (PVRIG), GenBank Accession No. NM_024070, a.a. 41-172, with C-terminal Fc-Fusion-Avi-tag, expressed in a HEK293 cell expression system and enzymatically biotin-labeled using AviTag™ technology. MW = 42 kDa.
Synonym(s): Poliovirus Receptor-related Immunoglobulin Domain-containing Protein, Transmembrane Protein PVRIG
Formulation: 8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Format: Aqueous buffer solution
Storage / Stability: At least 6 months at –80°C. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%).
Reference(s): 1. Bottino, C., et al., J. Exp. Med. 2003; 198(4): 557-567.
2. Pende, D., et al., Blood. 2005; 105(5): 2066-2073 Scientific Category: Immunotherapy
Product Type: Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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