| 产品名称 | Woodchuck PD-L1 / TCR Activator Mammalian Expression Kit - Stable Cell Lines & Cell-Based Assay Kits - Immunotherapy |
| 产品货号 | 79455 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 500 Reactions |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Background: The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated Tcells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
Description: The recombinant expression vectors are designed to express human engineered T cell receptor (TCR) activator and woodchuck (groundhog, Marmota monax) PD-L1 (GenBank Accession #HQ403651) in mammalian cells. The transfected cells can be used in conjunction with Woodchuck PD-1/NFAT Reporter/Jurkat T cells (BPS #79456) to study the interactions of PD-1 with PD-L1 ligand in a cellular context and screen for modulators of this signaling pathway.
Materials Required But Not Provided:
Synonym(s): Groundhog, Marmota Monax, PD-L1, Programmed Cell Death 1 Ligand 1, CD274, B7 Homolog 1, B7-H1, TCR
Format: COMPONENTS:
Instructions for use: See assay kit data sheet for detailed protocol.
Storage / Stability: Stable at least 6 months from date of receipt, when stored as directed.
Application(s): • Screen for activators or inhibitors of PD-1 signaling in a cellular context
• Characterize the biological activity of PD-1 and its interactions with ligands Warning(s): Avoid freeze/thaw cycles.
Scientific Category: Immunotherapy
Product Type: Assay Kit
Data shown is lot-specific. Contact us for specific information on other lots.
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