| 产品名称 | FALZ (BPTF), GST-tag |
| 产品货号 | 31134 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 100 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 41 kDa
Genbank #: NM_182641
Tag(s): N-terminal GST-tag
a.a: 2791–2911
Background: FALZ is a bromodomain-containing protein that is the histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on Lys4 (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. High levels of FALZ were detected in fetal brain and in patients with neurodegenerative diseases.
Description: Human Fetal Alzheimer Antigen (FALZ), also known as Fetal Alz-50 Clone 1 Protein or bromodomain PHD finger transcription factor (BPTF), GenBank Accession No. NM_182641, a.a. 2791-2911 corresponding to single bromodomain, with N-terminal GST-tag, MW=41 kDa, expressed in an E. coli cell expression system.
UniProt Q12830
Synonym(s): Fetal Alzheimer Antigen, FALZ, Fetal Alz-50 Clone 1 Protein, bromodomain PHD finger transcription factor, BPTF
Formulation: 40 mM Tris-HCl, pH 8, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.
Format: Aqueous buffer solution
Storage / Stability: Store at -80°C. Stable for >6 months when stored as directed. Application(s): Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Reference(s): 1. Buganim, Y., et al.,Structure. PLoS One. 2010;11;5(3):e9657.
2. Ruthenburg, A.J., et al., Cell. 2011;145(5):692-706. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Bromodomain
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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