| 产品名称 | Human Thymic stromal lymphopoietin - Cytokine(s) |
| 产品货号 | 90250-A |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 2 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 15 kDa
Genbank #: Q969D9
a.a: 29–159
Background: Thymic stromal lymphopoietin (TSLP) promotes the growth and activation of B cells. It also has wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells, basophils, eosinophils, mast cells, CD4?, CD8? and natural killer T cells, and epithelial cells. TSLP plays a role in the promotion of TH2 responses in lung- and skin-specific allergic disorders, and it also is involved in the blockade of TH1/TH17 responses and the promotion of cancer and autoimmunity.
Description: Recombinant TSLP is a disulfide-linked monomeric protein consisting of 132 amino acid residues, and migrates as an approximately 15 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human TSLP mature chain was expressed in E. coli.
UniProt Q969D9
Synonym(s): TSLP, Thymic stromal lymphopoietin
Purity: ≥95% by SDS-PAGE and HPLC
Endotoxin Level: <0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity: The ED50 was determined by the dose-dependent proliferation of human IL-7Rα and human TSLP R co-transfected mouse BaF3 cells to be < 3.0 ng/ml.
Formulation: Lyophilized from a 0.2 µm filtered 1 mg/ml solution of 20 mM phosphate buffer, pH 7.4, 150 mM NaCl.
Format: lyophilized protein
Reconstitution: Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.
Storage / Stability: The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles. Reference(s): 1. Ziegler SF, et al. Adv Pharmacol. 2013,66:129-55.
2. Yu X, et al. Cell Immunol. 2012 Oct,279(2):174-9. 3. Roan F, et al. J Leukoc Biol. 2012 Jun,91(6):877-86. Warning(s): Avoid freeze/thaw cycles
Amino Acid Sequence: YDFTNCDFEKIKAAYLSTISKDLITYMSGTKSTEFNNTVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ
Scientific Category: Cytokine/Growth Factors
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
Quality Assurance |
| 产品资料 |