| 产品名称 | Human Interleukin-31 - Cytokine(s) |
| 产品货号 | 90190-B |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 18 kDa
Genbank #: Q6EBC2
a.a: 24–164
Background: IL-31 is a recently discovered helical cytokine, belonging to the gp130/IL-6 cytokine family.The receptors for IL- 6 family are type I receptors, and they share a number of common structural motifs, such as the cytokine-binding domain with two pairs of conserved cysteine residues and a WSXWS sequence motif in the extracellular domain. IL-31 is expressed preferentially by activated Th2 CD4+ T cells, signaling through a heterodimeric receptor complex composed of IL-31RA and OSMR. Recent studies in both humans and mice have suggested a link between IL- 31/IL-31R expression and skin inflammation although the functional significance of endogenous IL-31/IL-31R interactions in influencing innate and adaptive immune responses remains unknown.
Description: Recombinant Interleukin-31 is a disulfide-linked monomer protein consisting of 142 amino acid residues, and migrates as an approximately 18 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Interleukin-31 mature chain was expressed in E. coli.
UniProt Q6EBC2
Synonym(s): IL-31, interleukin 31 , IL31
Purity: ≥95% by SDS-PAGE and HPLC
Endotoxin Level: <0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity: The ED50 was determined by the ability to induce STAT3 activation in U87MG cells, and was determined to be ≥ 7 ng/ml.
Formulation: Lyophilized from a 0.2 µm filtered PBS solution, pH 7.5.
Format: lyophilized protein
Reconstitution: Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.
Storage / Stability: The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles. Reference(s): 1. J. Immunol., May 2009, 182: 6088 - 6094.
2. Invest. Ophthalmol. Vis. Sci., Apr 2008, 49: 2531. 3. J. Exp. Med., Mar 2007, 204: 481 - 487. Warning(s): Avoid freeze/thaw cycles
Amino Acid Sequence: SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT
Scientific Category: Cytokine/Growth Factors
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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