| 产品名称 | Human Interleukin-21 - Cytokine(s) |
| 产品货号 | 90186-A |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 2 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 15 kDa
Genbank #: Q9HBE4
a.a: 25–155
Background: IL-21 stimulates proliferation of B-cell stimulated by crosslinking of the CD40 antigen. It inhibits proliferation stimulated by IL-4 plus anti-IgM. IL-21 augments stimulation of the proliferation of naive CD45RA(+) but not memory CD45R0(+) T-cells mediated by engagement of CD3. IL-21 stimulates the proliferation of bone marrow progenitor cells and the expression of the NK-cell marker CD56 in the presence of IL-15. The Interleukin-21 receptor is closely related to human IL-2 beta receptor. The receptor contains a WSXWS motif in the extracellular region, typical of type 1 cytokine receptors. The receptor is expressed on NK-cells, T- cells, and B-cell line. The functional signaling complex activates Janus kinases JAK1, JAK3, and the STAT proteins STAT1, and STAT3.
Description: Recombinant IL-21 is a disulfide-linked homodimeric protein consisting of 132 amino acid residues, and migrates as an approximately 15 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding murine Interleukin-21 mature chain was expressed in E. coli.
UniProt Q9HBE4
Synonym(s): Interleukin 21, IL-21, Za11, IL2
Purity: ≥97% by SDS-PAGE and HPLC
Endotoxin Level: <0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity: The ED50 was determined by the dose-dependent proliferation of activated B-cells.
Formulation: Lyophilized from 0.2 µm filtered PBS, pH 7.5.
Format: lyophilized protein
Reconstitution: Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.
Storage / Stability: The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles. Reference(s): 1. Pallikkuth, S., et al. Crit Rev Immunol. 2012,32(2):173-95.
2. Spolski, R., Leonard, W.J. Crit Rev Immunol. 2010,30(6):559-70. 3. MacDonald, T.T., et al. Biochem Soc Trans. 2011 Aug,39(4):1061-6. Warning(s): Avoid freeze/thaw cycles
Amino Acid Sequence: QDRHMI RMRQLIDIVD QLKNYVNDLV PEFLPAPEDV ETNCEWSAFS CFQKAQLKSA NTGNNERIIN VSIKKLKRKP PSTNAGRRQK HRLTCPSCDS YEKKPPKEFL ERFKSLLQKM IHQHLSSRTH GSEDS
Scientific Category: Cytokine/Growth Factors
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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