Anti-GITR recombinant human agonist antibody recognizing the GITRL binding region of human GITR. This antibody has not been tested for cross-reactivity with any other species.

glucocorticoid-induced TNF-related ligand, AITRL, CD357L, tumor necrosis factor ligand superfamily member 18, TNFSF18

Inhibition of GITR:GITRL interaction with anti-GITR antibody (BPS Bioscience,#79053) through GITR:GITRL TR-FRET Assay Kit (BPS Bioscience #79054). Data in the graphs are expressed as FRET ratios.

8 mM Na Phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl and 20% glycerol

Protein A affinity chromatography from HEK293 supernatants.

Stable for at least 12 months at -80°C. Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 – 0.5%) at 4°C, stable for 2 weeks.

This antibody crosslinked with FcGR2B is useful for activation of GITR costimulatory pathway in T cells

1. Cohen, A., et al., Cancer Research. 2006 May; 66(9): 4904-4912.

2. Scumpia, P.O., et al., Blood. 2007 Oct; 110(10):3673-3681.

Immunotherapy

Antibody