c-Met, also known as HGFR (hepatocyte growth factor receptor), is a receptor protein tyrosine kinase encoded by the gene MET. Upon binding its ligand HGF (hepatocyte growth factor), c-Met activates multiple cellular processes including proliferation, adhesion and angiogenesis. Importantly, many studies report that c-Met is overexpressed in various carcinomas, suggesting that targeting HGF/c-Met signaling could be a promising target for cancer treatment.
| 产品名称 | c-Met Kinase Assay Kit | |||||||||||||||||||||||||||
| 产品货号 | 79559 | |||||||||||||||||||||||||||
| 产品价格 | 现货询价，电话：010-67529703 | |||||||||||||||||||||||||||
| 产品规格 | 96 reactions | |||||||||||||||||||||||||||
| 产品品牌 | bpsbioscience | |||||||||||||||||||||||||||
| 产品概述 | ||||||||||||||||||||||||||||
| 产品详情 |
Background: Description: The c-Met Kinase Assay Kit is designed to measure c-Met kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. Materials Required But Not Provided: Kinase-Glo MAX (Promega #V6071) Dithiothreitol (DTT, 1 M; optional) Microplate reader capable of reading luminescence Adjustable micropipettor and sterile tips 30°C incubator Synonym(s): HGFR, hepatocyte growth factor receptor
Supplied As: The c-Met Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant c-Met enzyme, c-Met substrate, ATP and kinase assay buffer for 100 enzyme reactions.
Format:
Storage / Stability: Up to 6 months when stored as recommended.
Application(s): Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Reference(s): Sierra J. R., Ther. Adv. Med. Oncol. 3(1 Suppl): S21–S35 (2011) Warning(s): Avoid freeze/ thaw cycles
Scientific Category: Kinase
Product Type: Assay Kit
Data shown is lot-specific. Contact us for specific information on other lots.
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