产品名称 VEGFR3(FLT4) Kinase Assay Kit
产品货号 79738
产品价格 现货询价,电话:010-67529703
产品规格 96 reactions
产品品牌 bpsbioscience
产品概述
产品详情
Background:
Vascular endothelial growth factor receptor 3 (VEGFR3), also called Fms-Related Tyrosine Kinase 4 (FLT4), is a tyrosine kinase (TK) receptor for VEGFs that plays a central role in tumor angiogenesis; therefore, the inhibition of VEGFR3 is a promising therapeutic strategy for inhibiting angiogenesis and tumor growth.
Description:
The VEGFR3 Kinase Assay Kit is designed to measure VEGFR3 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
Materials Required But Not Provided:

ADP-Glo® Kinase Assay (Promega #V6930)
Dithiothreitol (DTT, 1 M; optional)
Microplate reader capable of reading luminescence
Adjustable micropipettor and sterile tips
30°C incubator

Synonym(s):
Vascular Endothelial Growth Factor Receptor 3, Fms Related Tyrosine Kinase 4, Tyrosine-Protein Kinase Receptor FLT4, Fms-Like Tyrosine Kinase 4, EC 2.7.10.1
Supplied As:
The VEGFR3 Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant VEGFR3 enzyme, VEGFR3 substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Format:

Assay Kit Components

Instructions for use:
See assay protocol for detailed instructions
Storage / Stability:
Up to 6 months when stored as recommended.
Application(s):
Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Reference(s):

Yeh, Yu-Wen et al. “Targeting the VEGF-C/VEGFR3 axis suppresses Slug-mediated
cancer metastasis and stemness via inhibition of KRAS/YAP1 signaling” Oncotarget vol.
8,3 (2016): 5603-5618.


Silvia M. Ferrari, et al. “Lenvatinib in the Therapy of Aggressive Thyroid Cancer: State of
the Art and New Perspectives with Patents Recently Applied”, Recent Patents on Anti-
Cancer Drug Discovery (2018) 13: 201.

Warning(s):
Avoid multiple freeze/thaw cycles.
Scientific Category:
Kinase
Product Type:
Assay Kit
Data shown is lot-specific. Contact us for specific information on other lots.

Quality Assurance

Product Datasheets

79738.pdf
产品资料