| 产品名称 | TPH2 Inhibitor Screening Assay Kit - Assay kits - Immunotherapy |
| 产品货号 | 72054 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 96 reactions |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Background: Tryptophan 5-hydroxylase 1 and 2 (TPH1 and TPH2) are enzymes that catalyze the monooxygenation of tryptophan to 5-hydroxytryptophan (5-HTP) which is subsequently converted to serotonin. By catalyzing the rate-limiting step in the biosynthesis of serotonin, these enzymes also play key roles in the signaling of other neurotransmitters downstream of serotonin synthesis, like melatonin. Additionally, TPH enzymes may play a role in immune regulation through tryptophan depletion.
Description: The TPH2 Assay Kit is designed to measure TPH2 enzyme inhibition in a 96 reaction format. This fluorescence-based assay kit is especially suitable for high throughput screening applications. The procedure is quick, straightforward, and simple - just mix two solutions, incubate, add quenching solution, and measure the fluorescence.
Synonym(s): tryptophan 5-hyrdoxylase, TRPH, activity assay kit
Format: COMPONENTS:
Instructions for use: See product datasheet for detailed protocol.
Storage / Stability: At least 6 months from date of receipt when stored as directed.
Application(s): Great for screening small molecular inhibitors for drug discovery and HTS applications.
Reference(s): 1. Moran G. R., et al. J. Biol. Chem. 1998; 273:12259-12266. Notes: MATERIALS REQUIRED BUT NOT SUPPLIED:
Microplate reader capable of measuring Fluorescence Warning(s): Avoid freeze/thaw cycles.
Scientific Category: Metabolic Enzyme, Immunotherapy
Product Type: Assay Kit
Data shown is lot-specific. Contact us for specific information on other lots.
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