| 产品名称 | TNFR2:TNF-alpha[Biotinylated] Inhibitor Screening Assay Kit - Assay kits - Immunotherapy | |||||||||||||||||||||||||||||||||||||
| 产品货号 | 79756 | |||||||||||||||||||||||||||||||||||||
| 产品价格 | 现货询价，电话：010-67529703 | |||||||||||||||||||||||||||||||||||||
| 产品规格 | 96 reactions | |||||||||||||||||||||||||||||||||||||
| 产品品牌 | bpsbioscience | |||||||||||||||||||||||||||||||||||||
| 产品概述 | ||||||||||||||||||||||||||||||||||||||
| 产品详情 |
Background: Tumor necrosis factor receptor 2 (TNFR2, TNFRSF1B or CD120b) is a membrane receptor that binds the pleiotropic pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). TNFR2 is predominately expressed in cells of the immune system, especially regulatory T cells, and by endothelial cells. TNFR2 exhibits neuroprotective properties and promotes tissue regeneration, making it a promising potential therapeutic target for the treatment of Alzheimer’s disease, autoimmune diseases and cancer.
Description: The TNFR2:TNF-alpha[Biotinylated] Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of TNFR2:TNF-alpha. The key to this kit is the high sensitivity of detection of biotin-labeled TNF-alpha by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, TNFR2 is coated on a 96-well plate. Next, biotinylated TNF-alpha is incubated with TNFR2 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can be measured using a chemiluminescence reader.
Materials Required But Not Provided: PBS (Phosphate buffered saline) Synonym(s): TNFR2, TNFRSF1B, CD120b
Supplied As: This kit comes in a convenient 96-well format, with biotin-labeled TNF-alpha, purified TNFR2, streptavidin-labeled HRP, and assay buffer for 96 binding reactions.
Format:
Instructions for use: See assay protocol for detailed instructions.
Storage / Stability: Up to 6 months from date of receipt, when stored as recommended.
Application(s): This kit is useful for screening for inhibitors of TNF-alpha binding to TNFR2.
Reference(s): Vanamee, ES., et al. Trends. Mol. Med. 2017, 23(11): 1037-1046 Chen, X., et al. Sci. Signal. 2017, 10(462): eaal2328 Ortí-Casañ. N., et al. Front. Neurosci. 2019, 13: 49 Warning(s): Avoid freeze/thaw cycles.
Scientific Category: Immunotherapy
Product Type: Assay Kit
Data shown is lot-specific. Contact us for specific information on other lots.
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