| 产品名称 | Mouse CD38 Inhibitor Screening Assay Kit (Hydrolase Activity) - Assay kits - Immunotherapy | ||||||||||||||||||||||||||
| 产品货号 | 79682 | ||||||||||||||||||||||||||
| 产品价格 | 现货询价，电话：010-67529703 | ||||||||||||||||||||||||||
| 产品规格 | 96 Reactions | ||||||||||||||||||||||||||
| 产品品牌 | bpsbioscience | ||||||||||||||||||||||||||
| 产品概述 | |||||||||||||||||||||||||||
| 产品详情 |
Background: CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein. It is also known as ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD) glycohydrolase. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic β cells. The major enzymatic activity of CD38 is the hydrolysis of NAD. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia.
Description: The Mouse CD38 Inhibitor Screening Assay Kit (Hydrolase Activity) is designed to measure the glycohydrolase activity of mouse CD38 for screening and profiling applications. The CD38 assay kit comes in a convenient 96-well format, with purified recombinant murine CD38 enzyme, its substrate N6-etheno-NAD (ε-NAD), and CD38 assay buffer for 96 enzyme reactions. In addition, the kit includes the CD38 inhibitor apigenin for use as a control inhibitor.
Materials Required But Not Provided: Adjustable micropipettor and sterile tips Fluorescent microplate reader Rotating or rocker platform Synonym(s): cluster of differentiation 38, cyclic ADP ribose hydrolase, activity assay kit
Format:
Instructions for use: See assay kit data sheet for detailed protocol
Storage / Stability: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival
Application(s): Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Reference(s): Wei, W., et al., World J. Biol. Chem. 2014 5(1):58-67. Lund, F., et al., Mol. Med. 2006 12(11-12):328-333. Warning(s): Avoid multiple freeze/thaw cycles
Scientific Category: Immunotherapy
Product Type: Assay Kit
Data shown is lot-specific. Contact us for specific information on other lots.
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