| 产品名称 | CD112R:CD112[Biotinylated] Inhibitor Screening Assay Kit - Immunotherapy |
| 产品货号 | 79732 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 96 reactions |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Background: CD112 (Poliovirus receptor-related 2, PVRL2), widely expressed on antigen-presenting cells and tumor cells, is the high affinity ligand of CD112R (Poliovirus receptor related immunoglobulin domain containing, PVRIG). CD112-CD112R interaction is a positive immune checkpoint that enhances human T cell response and it has emerged as an attractive therapeutic target for oncology. TIGIT (T cell immunoreceptor with Ig and ITIM domains) and CD226 (also called DNAM-1, DNAX Accessory Molecule-1) are other ligands of CD112.
Description: The CD112R:CD112[Biotinylated] Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of CD112R-CD112. The key to this kit is the high sensitivity of detection of biotin-labeled CD112 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, CD112R is coated on a 96-well plate. Next, CD112 is incubated with CD112R on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can be measured using a chemiluminescence reader.
Materials Required But Not Provided: PBS (Phosphate buffered saline) Synonym(s): Poliovirus receptor-related 2, PVRL2, Poliovirus receptor related immunoglobulin domain containing, PVRIG, immune checkpoint
Supplied As: This kit comes in a convenient 96-well format, with biotin-labeled CD112, purified CD112R, streptavidin-labeled HRP, and assay buffer for 100 binding reactions.
Format:
Instructions for use: See assay protocol for detailed instructions.
Storage / Stability: Up to 6 months from date of receipt, when stored as recommended.
Application(s): This kit is useful for screening for inhibitors of CD112 (PVRL2) binding to CD112R (PVRIG).
Reference(s): Zhu, Y., et al. J. Exp. Med. 2016, 213(2):167-76 Warning(s): Avoid multiple freeze/thaw cycles.
Scientific Category: Immunotherapy
Product Type: Assay Kit
Data shown is lot-specific. Contact us for specific information on other lots.
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