| 产品名称 | LILRB4 NFAT-Luciferase Reporter Jurkat Recombinant Cell Line - CAR T-Cell Therapy |
| 产品货号 | 79750 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 2 vials |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Background: Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4 (LILRB4) contains multiple Immunoreceptor Tyrosine-based Inhibitory Motifs (ITIMs). LILRB4 expression on Acute Myeloid Leukemia (AML) cells promotes tumor cell infiltration and suppresses T cell activity. Because LILRB4 is highly expressed on AML cells but not on normal hematopoietic stem cells, LILRB4 has been identified as a promising therapeutic target for CAR-T cells.
Description: Recombinant Jurkat cells constitutively expressing human LILRB4 (Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4, GenBank Accession #NM_001278426 and the firefly luciferase gene under the control of NFAT response elements.
Materials Required But Not Provided: Materials Required for Cell Culture Materials Required for Cellular Assay
Synonym(s): Eukocyte Immunoglobulin Like Receptor B4, CD85K
Supplied As: Each vial contains 2 x 10^6 cells in 1 ml of FBS with 10% DMSO.
Host Cell line: Jurkat
Growth Media: Thaw Medium 2 (BPS Bioscience #60184): RPMI1640 medium (Life Technologies #A10491-01) supplemented with 10% FBS (Life Technologies #26140-079), 1% Penicillin/Streptomycin (Hyclone #SV30010.01). Growth Medium 2F (BPS Bioscience #79669): Thaw Medium 2 plus 1 mg/ml of Geneticin (Life Technologies #11811031) and 200 μg/ml of Hygromycin B (Hyclone #SV30070.01). Instructions for use: See data sheet for detailed culturing and assay protocol.
Storage / Stability: Immediately upon receipt, store vials in liquid nitrogen.
Application(s): • Screen for novel ligands of LILRB4
Reference(s):
Notes: License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of BPS products to your laboratory. BPS does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact sales@bpsbioscience.com for details. Publications using this cell line should reference BPS Bioscience, Inc., San Diego. Warning(s): Avoid freeze/thaw cycles.
Scientific Category: CAR T-Cell Therapy
Product Type: Cell Line
Data shown is lot-specific. Contact us for specific information on other lots.
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