| 产品名称 | OX40[Biotinylated]:OX40L Inhibitor Screening Assay Kit - Biotinylation |
| 产品货号 | 72045 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 96 reactions |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Background: OX40 (CD134) is a co-stimulatory receptor expressed on the surface of T
cells. Binding of OX40 to its ligand, OX40L (CD252), present on dendritic cells, potentiates T
cell activation and T cell effector function. Studies have shown that OX40 agonists can increase
anti-tumor immunity and improve tumor-free survival in pre-clinical studies. Alternatively, OX40
antagonists offer potential as therapeutics for inflammatory diseases.
Description: The OX40[Biotinylated]:OX40L Inhibitor Screening Assay Kit is designed for
screening and profiling inhibitors of OX40:OX40L interaction. The key to this kit is the high sensitivity of detection of biotinlabeled
OX40 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for
the assay. First, OX40L is coated on a 96-well plate. Next, OX40-biotin is incubated with OX40L
on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP
substrate to produce chemiluminescence, which can then be measured using a
chemiluminescence reader.
Synonym(s): Tumor Necrosis Factor Receptor Superfamily Member 4, TNFRSF4, CD134, tumor necrosis factor ligand superfamily member 4, TNFSF4, CD252, activity assay kit, Strep HRP, streptavidin
Supplied As: This kit comes in a convenient 96- well format, with biotin-labeled OX40, purified OX40L, streptavidin-labeled HRP, and assay buffer for 100 binding reactions.
Format: COMPONENTS:
Instructions for use: See assay kit data sheet for detailed protocol
Storage / Stability: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Application(s): This kit is useful for screening for inhibitors of OX40 binding to OX40L.
Reference(s): 1. Peng, K., et al. 2014; AAPS J. 16(4): 625–633. Warning(s): Avoid freeze/thaw cycles.
Scientific Category: Immunotherapy
Product Type: Assay Kit
Data shown is lot-specific. Contact us for specific information on other lots.
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