| 产品名称 | Z-VEID-FMK - Inhibitors / Activators - Apoptosis |
| 产品货号 | 27669-1 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 5 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 652.7 Da
Formula: C31H45FN4O10
Target: Caspase 6
Background: VEID is the specific recognition sequence for caspase-6/Mch2. Caspase 6 is only one of at least three effector caspases, the others being caspase 3 and 7, that are active during caspasedependent apoptosisLoss of DNA-binding activity and TNFα-induced apoptosis can be prevented by Z-VEID-FMK. The caspase-6-speci?c inhibitor Z-VEID-FMK signi?cantly prevented apoptosis of caspase-6-microinjected neurons, and was also able to abolish the cleavage of procaspase-8, although caspase-6 is activated downstream of caspase-8 in Fas-mediated apoptosis.
Description: Z-VEID-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability. Can be used for both in vitro and in vivo studies--see note for using this product in vitro.
Synonym(s): fluoromethylketone; Benzyloxycarbonyl-Val-Glu(OMe)-Ile-?Asp(OMe)-fluoromethylketone
Purity: ≥90% by HPLC Biological Activity: We recommend using 2-10 µM for inhibiting caspase activity in cell culture. The optimal dose may vary for different cells and culture conditions.
Solubility: Soluble in DMSO (20 mM)
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Notes: The inhibitor is designed as a methyl ester to facilitate cell permeability. If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.
Amino Acid Sequence: Z-Val-Glu(OMe)-Ile-Asp(OMe)-CH?F
Scientific Category: Apoptosis Inhibitor
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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