Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 and SIRT2 inhibitor as well as an activator of the p53 pathway. Studies show that Tenovin-6 increases p53 levels more than Tenovin-1 and is also more toxic to yeast. Tenovin-6 has also been shown to inhibit SIRT3.

4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide

≥98% by HPLC

Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 µM, 10 µM, and 67 µM, respectively.

Soluble in DMSO

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

McCarthy, A.R, et al. Bioorg Med Chem. 2012 Mar 1;20(5):1779-93.

Deacetylase Inhibitor

Inhibitor