A cell permeable, synthetic peptide that irreversibly inhibits certain caspases. It is selective for caspase-5, but also shows some inhibition of caspase-1 and cathepsin B (IC50 = 6 µM).

We recommend using 2-10 µM for inhibiting caspase activity in cell culture. The optimal dose may vary for different cells and culture conditions.

Soluble in DMSO

Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed.

1. Heuer, D., et al. Nature, 457, 2009
2. Kamada, S., Fet al. (1997) Cell Death Diff. 4, 473-478.
3. Park, K., et al. Biochem Biophys Res Commun. 2006 Sep 8;347(4):941-8.

The inhibitor is designed as a methyl ester to facilitate cell permeability. If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.

Z-Trp-Glu(OMe)-His-Asp(OMe)-FMK

Apoptosis Inhibitor

Inhibitor