Vismodegib (GDC-0449) is a potent hedgehog (Hh) signaling pathway inhibitor.

≥99% by HPLC

Inhibits two ABC transporters, ABCG2/BCRP and ABCB1/Pgp, with IC50 values of 1.4 and 3.0 µM, respectively.

Soluble in DMSO at 200 mg/ml; soluble in ethanol at 10 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM

A crystalline solid.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Von Hoff, D.D., et al. N. Engl. J. Med. 361: 1164-1172 (2009).
2. Zhang, Y., et al. Neoplasia 11: 96-101 (2009).

Miscellaneous

Inhibitor