CHIR-99021 is a highly specific glycogen synthase kinase-3 (GSK-3) inhibitor that can inhibit both isoforms with IC50 of 10 nM (GSK-3α) and 6.7 nM (GSK-3β).

CHIR-99021; CT99021; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile

≥98% by HPLC

Soluble in DMSO

Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed.

1. Ring et al (2003). Diabetes 52 588.
2. Pan et al (2011). Neuropsychopharmacology 36 1397.
3. Ye et al (2012). PLoS One 7 e35892.

Wnt Signaling

Inhibitor