CDK5 is an unconventional member of the CDK family. It is expressed in post-mitotic neurons, and its activity is regulated by neuron-specific activators p35/p25 and p39 rather than the cyclins. It has been suggested that CDK5 plays several roles in the nervous system, including Tau aggregation and tangle formation. The CDK5 Assay Kit is designed to measure CDK5 activity for screening and profiling applications, using Kinase-Glo® MAX as a detection reagent.

CDKN5, cyclin-dependent kinase 5, cyclin dependent kinase 5

The CDK5 Assay Kit comes in a convenient 96-well format, with enough purified recombinant CDK5/p25 enzyme, CDK substrate peptide, ATP and kinase assay buffer for 100 enzyme reactions.

See assay kit data sheet for detailed protocol.

Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.

Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.

Uzma A. et. al., Nature Review Drug Discovery 14:130-146 (2015)

Avoid freeze/thaw cycles.

Kinase

Assay Kit