| 产品名称 | Mouse JNK1, GST-tag |
| 产品货号 | 40071 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Mouse
Host Species: Sf9 insect cells
MW: 71 kDa
Genbank #: NM_016700
Tag(s): N-terminal GST-tag
a.a: full length
Background: JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73 (1). JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction (2). JNK1 activity is also abnormally elevated in obesity and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity.
Description: Mouse JNK1 (GenBank Accession No. NM_016700), full length with N-terminal GST-tag, MW=71 kDa, expressed in a Baculovirus infected Sf9 cell expression system. The mouse amino acid sequence of JNK1 is identical to the one of human JNK1.
Synonym(s): JNK, JNK1, PRKM8, SAPK1, JNK1A2, JNK21B1/2
Purity: ≥90%
Specific Activity: 124 U/mg.
Unit Definition: One unit is defined as the amount of enzyme that will phosphorylate 1 nmol of 0.5 mg/ml ATF2 substrate per minute at pH 7.4 and 30°C.
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Derijard, B. et al. Cell. 1994 Mar 25,76(6):1025-37.
2. Kolodziejczyk, S M. et al. Curr Biol. 2001 Aug 21,11(16):1278-82. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Kinase/Serine-Threonine
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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