| 产品名称 | RbAp48, His-tag - Proteins - Other Proteins |
| 产品货号 | 50297 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 50 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells
MW: 48 kDa
Genbank #: NM_005610
Tag(s): N-terminal His-tag
a.a: 2–end
Background: RbAp48 is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; the NURF (nucleosome remodeling factor) complex; and the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes.
Description: Human RbAp48 (GenBank Accession No. NM_005610), a.a. 2-end with N-terminal His-tag, MW= 48 kDa, expressed in a baculovirus expression system.
UniProt Q09028
Synonym(s): RBAP48, Retinoblastoma Binding Protein 4, NURF55, Chromatin Assembly Factor 1 Subunit C, CAF1 p48, RBBP-4, Retinoblastoma-Binding Protein P48
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 200 mM imidazole
Format: Aqueous buffer solution
Storage / Stability: >6 months at -80°C Application(s): Useful for binding studies to investigate protein-protein interactions in the EZH2 complex. Also suitable as an immunogen or as a standard for Western blotting.
Reference(s): 1. Varambally, S. et al. Science 322 (5908), 1695-1699 (2008).
2. Rakotobe, D. et al., Virol. J. 5, 32 (2008). Warning(s): Avoid freeze/thaw cycles
Scientific Category: Miscellaneous
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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