| 产品名称 | L3MBTL1, GST-tag |
| 产品货号 | 55000 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 100 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 65.5 kDa
Genbank #: NM_015478
Tag(s): N-terminal GST-tag
a.a: 191–530
Background: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyl-lysine residues on target proteins, therey acting as a reader of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E atLys26 (H1bK26me1 and H1bK26me2) and histone H4 at Lys-20 (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at Lys-382, leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at Lys-860. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
Description: Human lethal(3)malignant brain tumor-like protein 1 (L3MBTL1), GenBank Accession No. NM_015478, a.a. 191-530 with N-terminal GST-tag, MW = 65.5 kDa, expressed in an E. coli cell expression system.
UniProt Q9Y468
Synonym(s): lethal(3) malignant brain tumor-like protein 1, L3MBTL1
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 1 mM DTT, 20 mM glutathione, and 20% glycerol
Format: Aqueous buffer solution
Storage / Stability: ≥ 6 months at -80°C Application(s): Useful for the study of Polycomb group (PcG) proteins, protein binding assays, screening inhibitors, and selectivity profiling.
Reference(s): 1. Koga, H., et al., Oncogene. 1999 Jul 1;18(26):3799-809. Warning(s): Avoid freeze/thaw cycles
Scientific Category: Methyl-lysine Reader
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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