PR-619 is a non-selective, reversible inhibitor of deubiquitinases/deubiquitylases (DUBs) and ubiquitin-like isopeptidases. PR-619 inhibits many deubiquitinating enzymes in the 5-20 μM range. Additionally, PR-619 is cell permeable and treatment of cells results in the accumulation of both ubiquitin and sumo-conjugated proteins.

Thiocyanic acid, C,C′–(2,6–diamino–3,5–pyridinediyl) ester

≥95% by HPLC.

Soluble in DMSO (10 mM)

Dry powder

Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 3 months. Avoid freeze/thaw cycles of solutions.

Useful for non-specific inhibition of ubiquitin-like isopeptidases for cell biology and drug discovery studies.

Protect from moisture. Avoid freeze/thaw cycles.

Ubiquitin Enzymes

Inhibitors/Activators