| 产品名称 | P005091 - Inhibitors / Activators - Ubiquitination |
| 产品货号 | 27767-2 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 50 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 348.2 Da
CAS Registry #: 882257-11-6
Formula: C12H7Cl2NO3S2
Target: USP7
Background: USP7, known as herpes-associated-ubiquitin-specificprotease (HAUSP), is a deubiquitylating enzyme that regulates the levels of the oncoprotein HDM2 and its substrate, the tumor suppressor p53. P005091 accelerated the degradation of HDM2, while analogs of the compound induced dose- and time-dependent increases in the protein levels of p53 and p21. P005091 induced apoptosis in numerous cancer cell lines, including both p53+/+ and p53-mutant cancer cell lines. P005091 also downregulated claspin and phosphorylation of the DNA checkpoint kinase Chk1.
Description: P005091 is a selective, potent inhibitor of USP7 deubiquitylating activity.
Synonym(s): P005091; P5091
Biological Activity: Selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 µM). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity on USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo.
Solubility: Soluble in DMSO
Storage / Stability: Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Scientific Category: Deubiquitinase Inhibitor
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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