Celastrol is a naturally occurring triterpenoid antioxidant compound with anti-inflammatory activity. Inhibits NFkappaB (IC50 = 270 nM). It induces heat shock response and cytoprotection in various cells. Celastrol inhibits 20S proteasome chymotrypsin-like activity (IC50 = 2.5 μM). Cell permeable.

Tripterine

>98% by TLC.

Soluble in DMSO (45 mg/ml) or Ethanol (30 mg/ml)

Red powder

Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 month.

Useful for inhibition of NF-kappa-B-dependent pathways and inhibition of 20S proteasome chymotrypsin-like activity.

1. Sethi, G., et al. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation. Blood, 2007, 109:2727.
2. Westerheide, S.D. et al. Celastrols as inducers of the heat shock response and cytoprotection. J. Biol. Chem. 2004. 279:56053.
3. Kiaei, M., et al. Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Neurodegener. Dis. 2005, 2:246.

Protect from light. Protect from moisture. Avoid freeze/thaw cycles.

Ubiquitin Enzymes

Inhibitors/Activators