(R)-MG132 is a potent, cell permeable and reversible inhibitor of proteasomes. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. In comparison to (S)-MG132, the (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities.
| 产品名称 | MG132 |
| 产品货号 | 27226 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 1 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 475.6 Da
CAS Registry #: 1211877-36-9
Formula: C26H41N3O5
Description: Synonym(s): MG132
Purity: ≥98% by HPLC Biological Activity: (R)-MG132 inhibits ChTL, TL and PGPH with IC50 values of 0.22 µM, 34.4 µM, and 2.95 µM, respectively.
Solubility: Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in these
solvents is approximately 25 mg/ml
Format: A crystalline solid.
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s): 1. Lee, D.H., et al., Trends Cell Biol. 1998;8:397-403
2. Elliot, P.J., et al., J. Mol. Med. 2003;81:235-245 3. Mroczkiewicz, M., et al., J. Med. Chem. 2010;53:1509-1518. Scientific Category: Ubiquitin
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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