| 产品名称 | AMSH Core Domain, His-tag - Deubiquitylating Enzymes - Ubiquitination |
| 产品货号 | 81081 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 25 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 20.5 kDa
Tag(s): His-tag
a.a: 250–424
Background: AMSHcore (Associated Molecule with the SH3-domain of STAM) is a JAMM domain-containing protein that regulates receptor endosomal sorting of the epidermal growth factor receptor (EGFR). Recombinant AMSH functions as a deubiquitylase in vitro and ablation of AMSH activity by incubation of cells with AMSH siRNA enhances the degradation of EGFR. AMSHcore mediated cleavage of K63 linked ubiquitin chains is enhanced in the presence of its binding partner STAM. AMSHcore contains only the core domain of AMSH protein.
Description: Human AMSH Core Domain recombinant protein, a.a. 250–424, with His-tag, expressed in E. coli.
UniProt Q96FJ0
Synonym(s): Associated molecule with the SH3 domain of STAM, STAMBP, MGC126516, MGC126518, STAM-binding protein
Format: Aqueous buffer solution
Storage / Stability: Store at or below –80°C. Stable as supplied for up to 1 year when stored dessicated at –80°C. Application(s): This enzyme cleaves K63-linked ubiquitin chains in vitro. Suggested Substrate: DiUbiquitin K63
Reference(s): 1. McCullough, J., et al. AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol, 2004. 166(4): p. 487-92.
2. McCullough, J., et al. Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. Curr Biol, 2006. 16(2):p. 160-5. Warning(s): Avoid freeze/thaw cycles.
Scientific Category: Deubiquitinase
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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