| 产品名称 | PTP-D2/PTPN14, GST-tag - Non-Receptor - Protein Phosphatase(s) |
| 产品货号 | 30025 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 20 µg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: E. coli
MW: 61 kDa
Genbank #: NM_005401
Tag(s): N-terminal GST-tag
a.a: 891-1187(end)
Background: Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a
negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
Description: PPTP-D2 (also known as Pez, PTP36 or PTPN14), Genbank accession number NM_005401, a.a. 891- 1187(end), with N-terminal GST tag, MW=61 kDa, expressed in an E. coli expression system.
Synonym(s): PTP-D2, PTPN14, Protein tyrosine phosphatase D2, Pez, PTP36
Specific Activity: 152 U/µg
Assay Conditions: 20 mM HEPES, pH 7.2, 100 mM NaCl, 2 mM EDTA, 1 mM DTT, 1 mM pNPP and PTPase. Assay was done at RT for 15 min, and the reaction was monitored at 405 nm continuously. Specific activity was calculated based on ε pNPP= 18,000 M-1cm-1.
Formulation: 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
Format: Aqueous buffer solution
Storage / Stability: >12 months at -80°C. Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s): 1. Wadham, C. et al., J.Cell. Sci. 2000, 113: 3117-3123.
2. Ogata, M. et al. J. Biol.Chem. 1999, 274: 20717-20724. Warning(s): Avoid freeze/thaw cycles
Scientific Category: PTP/Non-rec.
Product Type: Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
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