| 产品名称 | KW-2478 - Inhibitors / Activators - Protease(s) |
| 产品货号 | 27758-2 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 50 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 574.7 Da
CAS Registry #: 819812-04-9
Formula: C30H42N2O9
Target: HSP90
Background: Heat shock protein 90 (Hsp90) is a promising target for anti-tumor therapy. KW-2478 enhanced bortezomib-induced cell growth inhibition, and exhibited enhanced anti-tumor activity against human myeloma.
Description: KW-2478 is a novel and potent nonansamycin inhibitor of heat shock protein 90 (IC50 = 3.8 nM) designed to overcome the limitations, including low water solubility and hepatotoxicity, of 17-allylamino-17-demethoxygeldanamycin (17-AAG). KW-2478 exerts a strong antitumor activity against multiple myeloma (MM) cells with various chromosormal translocations. KW-2478 inhibits cell growth and apoptosis associated with Hsp90 client protein degradation. Recent study results have revealed that KW-2478 is able to deplete Hsp90 client Cdk9 and the phosphorylated 4E-BP1, a transcriptional kinase and a transcription inhibitor respectively, leading to reduced expression of FGFR3, c-Maf and cyclin D1.
Synonym(s): KW 2478; KW2478
Solubility: Soluble in DMSO
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): 1. Nakashima T, et al. Clin Cancer Res. 2010; 16(10): 2792-802.
2. Ishii, T., et al. Blood Cancer J. 2012 Apr;2(4):e68. Scientific Category: HSP Inhibitor
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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