Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity and calpain activity. Aclarubicin acts by forming a stable complex with DNA. It was originally identified as an antitumor agent. Cell permeable.

Aclarubicin, Jaclacin

≥95% by TLC.

Soluble in DMSO (30 mg/ml)

Orange powder

Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 month.

Useful for as a potent, cell permeable proteasome inhibitor for drug discovery research.

1. Figueiroda-Pereira, M.E., et al.; J. Biol. Chem. 1996, 271: 16455

Protect from light. Protect from moisture. Avoid freeze/thaw cycles.

Protease

Inhibitors/Activators