A cell-permeable, water-soluble, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 µM). Does not act as an antioxidant at higher concentrations (1 µM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke.

N-(5,6-Dihydro-6-oxo-2-phenanthridi­nyl)-2-acetamide hydrochloride

≥98%

Soluble to 100 mM in water and to 100 mM in DMSO

White to light brown powder.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Huang, S.H., et al. Oncol Rep. 2008 Sep;20(3):567-72.

Hygroscopic. Protect from Moisture. Protect from light.

PARP

Inhibitor