| 产品名称 | JW 55 - Inhibitors / Activators - PARP(s) |
| 产品货号 | 27633-1 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 434.5 Da
CAS Registry #: 664993-53-7
Formula: C25H26N2O5
Target: TNKS1, TNKS2
Background: Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.
Description: Cell-permeable, reversible tankyrase 1 (PARP5a) and tankyrase 2 (PARP5b) inhibitor. Also inhibits the β-catenin mediated canonical Wnt pathway
Synonym(s): N-[4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide
Purity: ≥98% by HPLC Biological Activity: JW55 decreased auto-PARsylation of TNKS1 and TNKS2 in vitro with IC50 values of 1.9 µM and 830 nM respectively.
Solubility: Soluble in DMSO
Storage / Stability: Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Reference(s): Waaler, J. et al. (2012). Cancer Res. 72 2822-32.
Scientific Category: PARP Inhibitor
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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