| 产品名称 | INO-1001 - Inhibitors / Activators - PARP(s) |
| 产品货号 | 27631-2 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 136.2 Da
CAS Registry #: 3544-24-9
Formula: C7H8N2O
Background: INO-1001 can sensitize cells to radiation in vitro by inhibiting the repair of DNA damage, presumably via PARP inhibition. INO-1001 is currently in phase 2 clinical trials and has shown positive effects for stroke, myocardial infarction, GI tract inflammation, anddiabetic endothelial dysfunction.
Description: INO-1001 is a novel, potent inhibitor of PARP. Also acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.
Synonym(s): 3-aminobenzamide
Purity: ≥98% by HPLC Biological Activity: INO-1001 is a novel potent PARP inhibitor with an IC50 of 3 nM. Exhibits IC50 of < 50 nM in CHO cells.
Solubility: Soluble in DMSO
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): 1. Szabo, G., et al. Shock. 2004 May;21(5):426-32.<
2. Mason, K.A., et al. Invest New Drugs. 2008 Feb;26(1):1-5. Scientific Category: PARP Inhibitor
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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