| 产品名称 | AZD2461 - Inhibitors / Activators - PARP(s) |
| 产品货号 | 27606-1 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 5 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 395.4 Da
CAS Registry #: 1174043-16-3
Formula: C22H22FN3O3
Background: Unlike treatment with AZD 2281 (Olaparib, Axon 1464), AZD 2461 succesfully circumvents drug resistance of Pgp-proficient tumors, and inactivation of p53-binding protein 1 (53BP1) as a causal factor in PARPi resistance.
Description: AZD2461 is a novel PARP inhibitor with low affinity for than Olaparib. AZD2641 is currently in Phase I clinical studies to treat solid tumors.
Synonym(s): 4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one
Purity: ≥98% by HPLC Biological Activity: PARP inhibitor (IC50 = 5 nM)
Solubility: Soluble in DMSO
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): J.E. Jaspers et al. Cancer Discov. 2013, 3, 68-81.
Scientific Category: PARP Inhibitor
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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