AZD2281, also known as Olaparib, is a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor and an anti-cancer drug being tested in patients with mutations in the genes BRCA1 or BRCA2.

AZD-2281] [KU-59436

≥95% by HPLC

Olaparib (AZD2281) is a potent PARP inhibitor with IC50 of 1.1 nM for PARP1 using the BPS Bioscience PARP1 Assay Kit (Cat. # 80551). It inhibits PARP2 with IC50 = 0.9 nM for using the BPS Bioscience PARP2 Assay Kit (Cat. # 80552).

Soluble in DMSO at 33 mg/ml; soluble in ethanol at 1.7 mg/ml with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM buffers, serum, or other additives may increase or decrease the aqueous solubility.

White to off-white crystalline solid; granular or powder.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. De Murcia, J., et al., Proc. Natl. Acad. Sci. USA 94: 7303 – 7307 (1997)
2. Bryant, H.E., et al., Nature 434: 913 – 915 (2005)
3. Farmer, H., et al., Nature 434: 917 – 921 (2005)

PARP

Inhibitor