| 产品名称 | BMN 673 - PARP(s) |
| 产品货号 | 27609-2 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 50 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 380.4 Da
CAS Registry #: 1207456-01-6
Formula: C19H14F2N6O
Target: PARP1
Background: BMN673 has shown anti-tumor activity both in vitro and in vivo. It inhibited proliferation of tumor cells and xenografts with defects in homologous recombination. The combination of BMN673 and DNA-damaging agents demonstrated synergistic anti-tumor effects. In addition, study showed that the expression levels of DNA repair proteins and status of PI3K pathway predict response to BMN673 in small cell lung cancer. BMN673 is currently under investigation in multiple clinical trials for advanced solid tumors or hematological malignancies, either as monotherapy or in combination with other anti-tumor agents.
Description: BMN673 is a potent and selective PARP1/2 inhibitor with Ki of 1.2 and 0.9 nM, respectively.
Synonym(s): (8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-1H-pyrido[4,3,2-de]phthalazin-3(2H)-one
Purity: ≥98% by HPLC Biological Activity: BMN673 showed IC50 value of 0.57 nM in enzymatic assay of PARP1 1. In in vitro assay, it exhibited greater potency than other existing PARP inhibitors, such as veliparib, rucaparib, and olaparib. It is much more potent at trapping PARP-DNA complexes than other PARP inhibitors.
Solubility: Soluble in DMSO
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): 1. Shen Y, et al. Clin Cancer Res 2013; 19: 5003-5015.
2. Cardnell RJ, et al. Clin Cancer Res 2014; 20: 2237. 3. Murai J, et al. Mol Cancer Ther 2014; 13: 433-443. 4. Cardnell RJ, et al. Clin Cancer Res 2013; 19: 6322-6328. Scientific Category: PARP Inhibitor
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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