The fluorogenic PDE substrate FAM-cGMP is used for cGMP-dependent phosphodiesterase assays. It has been used in activity assays for PDE5, PDE6 and PDE9.

2 {2'-(6-[Fluoresceneinyl] aminohexylcarbamoyl)guanosine-3',5'-cyclic monophosphate}

≥95% by HPLC

1 mM in aqueous solution (100 µl)

Store at -20°C. Stability: At least 6 months from date of receipt, when stored as directed

Useful for assaying phosphodiesterase activity, and for screening of small molecule inhibitors for drug discovery and HTS applications.

Avoid freeze/thaw cycles.

PDE

Substrate