CP 80633 is a selective inhibitor of PDE4, which does not display significant isozyme selectivity. It also inhibits hydrolysis of cAMP in isolated monocytes, eosinophils, human peripheral blood and T-cells. It has been shown to exhibit anti-inflammatory and bronchodilatory activity in vivo.

≥95% by HPLC

CP-80633 inhibits PDE4 isozymes (human lung IC50 = 1.27 µM) in the absence of effects on PDE1, PDE2, PDE3 and PDE5 isozymes (IC50 > 100 µM).

Soluble in 100 mM DMSO or 100 mM Ethanol.

A crystalline solid.

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Turner, CR., et al., J. Pharmacol. Exp. Ther. 1996 Sept;278(3):1349-55.
2. Cohan, VL., et al., J. Pharmacol. Exp. Ther. 1996 Sept;278(3):1356-61.
3. Cheng, JB., et al., J. Pharmacol. Exp. Ther. 1997 Feb;280(2):621-6.

PDE

Inhibitor