| 产品名称 | Ruxolitinib, Phosphate - Kinase Inhibitors - Kinase(s) |
| 产品货号 | 27059 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 10 mg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
MW: 404.3 Da
CAS Registry #: 1092939-17-7
Formula: C17H18N6•H3O4P
Description: Ruxolitinib, also known as INCB18424, is a potent and selective Janus kinase JAK1 and JAK2 inhibitor, with IC50s of 5.9 nM and 5.7 nM, respectively. It inhibited IL-6 and IL-23 effects at concentrations less than 50 nM. Ruxolitinib was effective in the rat adjuvant arthritis model and multiple murine models of arthritis.
Synonym(s): INCB18424
Purity: ≥99% Solubility: Soluble in DMSO at 200 mg/ml; very poorly soluble in ethanol; soluble in water at 8 mg/ml
Format: white powder.
Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s): Fridman, J.S., et al. J. Immunol. 184: 5298-5307 (2010).
Scientific Category: Kinase
Product Type: Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
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