| 产品名称 | 14-3-3 zeta Protein, His-tag (Human) - Kinase Substrates - Kinase(s) |
| 产品货号 | 79039 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | 20 μg |
| 产品品牌 | bpsbioscience |
| 产品概述 | |
| 产品详情 |
Species: Human
Host Species: Sf9 insect cells using baculovirus
MW: 31 kDa
Genbank #: NM_012479
Tag(s): N-terminal His tag
a.a: Full length
Background: 14-3-3 zeta (also known as tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 zeta protein plays a key role in cancer biology by being an important regulator of major cellular processes such as proliferation, differentiation, senescence and apoptosis (1). 14-3-3 zeta protein has been shown to interact with the IRS1 protein, suggesting a role for this protein in regulating insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (2).
Description: Human 14-3-3 zeta Protein, GenBank Accession No. NM_012479, full length, with N-terminal His-tag, expressed in Sf9 insect cells using baculovirus. MW = 31 kDa.
Synonym(s): 14-3-3 zeta, YWHAZ, KCIP-1, MGC111427, MGC126532, MGC138156
Formulation: 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol
Storage / Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Application(s): Western blot
Reference(s): 1. Li, Z. et al: Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation. Proc Natl Acad Sci U S A. 2008; 105(1):162-7.
2. Niemantsverdriet, M. et al: Cellular functions of 14-3-3 zeta in apoptosis and cell adhesion emphasize its oncogenic character. Oncogene. 2008;27(9):1315-9. 2007. Scientific Category: Kinase
Product Type: Protein
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